Protocolos de tratamiento a la COVID-19: aproximación desde una perspectiva farmacoterapéutica
DOI:
https://doi.org/10.46502/issn.2710-995X/2022.7.02Palabras clave:
COVID-19, efectividad, eficacia, protocolos, seguridad.Resumen
La introducción de los protocolos y guías de actuación clínica en los contextos sanitarios ha jugado un papel esencial en el combate a la COVID-19. Es por ello que el presente trabajo muestra los resultados derivados de una revisión narrativa realizada para describir el diseño e implementación de protocolos para el tratamiento a la COVID-19 en diferentes contextos sanitarios, desde el análisis de criterios farmacoterapéuticos. La metodología de Zillmer de 2018 fue utilizada, estableciéndose criterios para la inclusión de las publicaciones. De acuerdo con este criterio fueron identificadas 48 publicaciones, entre las que se incluyeron publicaciones originales, ensayos clínicos, estudios de revisión, descriptivos y de intervención. Se analizaron las intervenciones farmacológicas realizadas por cinco protocolos correspondientes a la Organización Mundial de la Salud (OMS), Brasil, Estados Unidos, China y Cuba. Las guías de la OMS y Estados Unidos realizaron recomendaciones a favor del uso de corticoesteroides sistémicos y anticuerpos monoclonales y no recomendaron el uso de hidroxicloroquina, lopinavir/ritonavir y remdesivir (solo en el caso de la OMS) basados en los resultados de los ensayos RECOVERY, REMAP-CAP y SOLIDARITY. China y Cuba recomiendan el uso de la cloroquina, lopinavir/ritonavir y los interferones. Cuba recomienda el uso de anticuerpos monoclonales entre los que resaltan nuevos productos que evidencian el avance de su investigación biotecnológica. Por su parte el protocolo de Brasil abarca limitadas recomendaciones entre las que se encuentra evitar el uso de corticoesteroides sistémicos. La generalidad de medicamentos utilizados para el tratamiento de la COVID-19 carecen de evidencia científica suficiente que respalde su uso y actualmente se encuentran en fase de investigación, por lo que los protocolos están sujetos a cambios conforme avanzan dichas investigaciones. Sin embargo, la información científica disponible y basada en la evidencia, ha contribuido a la toma de decisiones farmacoterapéuticas para el enfrentamiento a la pandemia en los países.
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Brasil Mdsd. (2020). Protocolo de Tratamento do Novo Coronavírus (2019-nCoV). https://portalarquivos2.saude.gov.br/images/pdf/2020/fevereiro/05/Protocolo-de-manejo-clinico-para-o-novo-coronavirus-2019-ncov.pdf
Cano, E. J., Fuentes, X. F., Campioli, C. C., O’Horo, J. C., Saleh, O. A., Odeyemi, Y., Yadav, H., & Temesgen, Z. (2021). Impact of corticosteroids in coronavirus disease 2019 outcomes: systematic review and meta-analysis. Chest, 159(3), 1019-1040. https://www.sciencedirect.com/science/article/pii/S0012369220351072
Cantini, F., Goletti, D., Petrone, L., Fard, S. N., Niccoli, L., & Foti, R. (2020). Immune therapy, or antiviral therapy, or both for COVID-19: a systematic review. Drugs, 1-18. https://europepmc.org/article/MED/33068263
Caponi, S., Brzozowski, F. S., Hellmann, F., & Bittencourt, S. C. (2021). O uso político da cloroquina: COVID-19, negacionismo e neoliberalismo/The political use of chloroquine: COVID-19, denialism and neoliberalism. Revista Brasileira de Sociologia-RBS, 9(21), 78-102. http://www.sbsociologia.com.br/rbsociologia/index.php/rbs/article/view/rbs.774
Casadevall, A., Dadachova, E., & Pirofski, L. A. (2004). Passive antibody therapy for infectious diseases. Nature Reviews Microbiology, 2(9), 695-703. https://pubmed.ncbi.nlm.nih.gov/15372080/
Casadevall, A., & Pirofski, L. A. (2020). The convalescent sera option for containing COVID-19. The Journal of clinical investigation, 130(4), 1545-1548. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108922/
Cavalcanti, A. B., Zampieri, F. G., Rosa, R. G., Azevedo, L. C., Veiga, V. C., Avezum, A. (2020). Hydroxychloroquine with or without azithromycin in mild-to-moderate Covid-19. New England Journal of Medicine, 383(21), 2041-2052. https://www.ncbi.nlm.nih.gov/pubmed/32706953
CECMED. Autorización de Uso de Emergencia (AUE) del producto Jusvinza. https://www.cecmed.cu/covid-19/aprobaciones/jusvinza-cigb-258-1
Choi, Y.J., Park, J.Y., Lee, H.S., Suh, J., Song, J.Y., Byun, M.K., Cho, J.H., Kim, H.J., Lee, J.H., Park, J.W., & Park, H.J. (2021). Effect of asthma and asthma medication on the prognosis of patients with COVID-19. European Respiratory Journal, 57(3). DOI: 10.1183/13993003.02226-2020
Chun Yam L.Y., Wing Lau A. C., Lin Lai F. Y., Shung E., Chan, J., & Wong, V. (2007). Corticosteroid treatment of severe acute respiratory syndrome in Hong Kong. Journal of Infection, 54(1), 28-39. https://www.sciencedirect.com/science/article/abs/pii/S0163445306000090
Ciapponi, A. (2020). El escándalo de la cloroquina. Evidencia, actualizacion en la práctica ambulatoria, 23(3), e002073-e002073. http://evidencia.org/index.php/Evidencia/article/view/6862
da Costa Braúna, C., Araujo, P. M., Carvalho, R. D., de Medeiros, M. D., & Nunes, L. C. (2021). Farmacoeconomia aplicada ao tratamento medicamentoso para a COVID-19 em um hospital campanha. Revista Eletrônica Acervo Saúde, 13(2). https://acervomais.com.br/index.php/saude/article/view/5971/4191
Descriptores en Ciencias de la Salud: DeCS. (2017). Sao Paulo (SP): BIREME / OPS / OMS. http://decs.bvsalud.org/E/homepagee.htm
Díaz, Y., Ramos-Suzarte, M., Martín, Y., Calderón, N. A., Santiago, W., Viñet, O., La O, Y., Oyarzábal, J., Pérez, Y., Lorenzo, G., Cepeda, M., Saavedra, D., Mazorra, Z., Estevez, D., Lorenzo-Luaces, P., Valenzuela, C., Caballero, A., Leon, K., Crombet, T., & Hidalgo, C.J. (2020). Use of a humanized anti-CD6 monoclonal antibody (itolizumab) in elderly patients with moderate COVID-19. Gerontology, 66(6), 553-561. https://pubmed.ncbi.nlm.nih.gov/33105142/
Dong, L., Hu, S., & Gao, J. (2020). Discovering drugs to treat coronavirus disease 2019 (COVID-19). Drug discoveries & therapeutics, 14(1), 58-60. https://pubmed.ncbi.nlm.nih.gov/32147628/
Food and Drug Administration. (2020). Fact sheet for healthcare providers: emergency use authorization (EUA) of bamlanivimab https://www.fda.gov/media/143603/download
Food and Drug Administration. (2020). Fact sheet for healthcare providers: emergency use authorization (EUA) of casirivimab and imdevimab. https://www.fda.gov/media/143892/download
Food and Drug Administration (2020). Remdesivir (VEKLURY). https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/214787Orig1s000lbl.pdf.
Gendrot, M., Javelle, E., Clerc, A., Savini, H., & Pradines, B. (2020). Chloroquine as a prophylactic agent against COVID-19? https://www.researchgate.net/publication/340597303_Chloroquine_as_prophylactic_agent_against_COVID-19
Gorbalenya A. E., Baker S. C., Baric, R.S., Groot, R.J., Drosten, C., Gulyaeva, A.A., Haagmans, B.L., Lauber, C., Leontovich, A.M., Neuman, B.W., Penzar, D., Perlman, S., Poon, L.L., Samborskiy, D.V., Sidorov, I.A., Sola, I., & Ziebuhr, J. (2020). The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nature microbiology, 5(4), 536. https://www.nature.com/articles/s41564-020-0695-z
Herrera, D., & Gaus, D. (2020). Enfermedad por covid-19 o sars-cov-2: guía clínica y de manejo. Práctica Familiar Rural, 5(1). https://practicafamiliarrural.org/index.php/pfr/article/view/146/188
Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., ... & Pöhlmann, S. (2020). SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. cell, 181(2), 271-280. https://www.sciencedirect.com/science/article/pii/S0092867420302294
Li, G., & De Clercq, E. (2020). Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nature reviews Drug discovery, 19(3), 149-150. https://pubmed.ncbi.nlm.nih.gov/32127666/
Liang, T. (2020). Handbook of COVID-19 prevention and treatment. The First Affiliated Hospital, Zhejiang University School of Medicine. Compiled According to Clinical Experience, 68. https://www.ephi.gov.et/images/novel_coronavirus/Handbook-of-COVID-19-Prevention-and-Treatment.pdf
Liu, J., Cao, R., Xu, M., Wang, X., Zhang, H., Hu, H., ... & Wang, M. (2020). Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. Cell discovery, 6(1), 1-4. https://www.ncbi.nlm.nih.gov/%20pubmed/32194981
Mehra, M. R., Desai, S. S., Ruschitzka, F., & Patel, A. N. (2020). RETRACTED: Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2820%2931180-6/fulltext
Mehta, P., McAuley, D. F., Brown, M., Sanchez, E., Tattersall, R. S., & Manson, J. J. (2020). COVID-19: consider cytokine storm syndromes and immunosuppression. The lancet, 395(10229), 1033-1034. https://pubmed.ncbi.nlm.nih.gov/32192578/
MeSH. (2002). U.S: National Library of Medicine. https://www.ncbi.nlm.nih.gov/mesh/
MINSAP. Protocolo de Actuación Nacional para la COVID-19 versión 1.1. (2021) https://covid19cubadata.github.io/protocolos/protocolo-version-1.pdf.
MINSAP. Protocolo de Actuación Nacional para la COVID-19 versión 1.2. (2021) https://covid19cubadata.github.io/protocolos/protocolo-version-2.pdf.
MINSAP. Protocolo de Actuación Nacional para la COVID-19 versión 1.3. (2021) https://covid19cubadata.github.io/protocolos/protocolo-version-3.pdf.
MINSAP. Protocolo de Actuación Nacional para la COVID-19 versión 1.4. (2021) https://covid19cubadata.github.io/protocolos/protocolo-version-4.pdf.
MINSAP. Protocolo de Actuación Nacional para la COVID-19 versión 1.5. (2021) https://covid19cubadata.github.io/protocolos/protocolo-version-5.pdf.
MINSAP. Protocolo de Actuación Nacional para la COVID-19 versión 1.6. (2021) https://covid19cubadata.github.io/protocolos/protocolo-version-6.pdf
NIH. COVID-19 Treatment Guidelines Panel. (2021) Coronavirus Disease 2019 (COVID-19) Treatment Guidelines. https://www.covid19treatmentguidelines.nih.gov/
NIH. U.S. National Library of Medicine. Clinical Trials. (2021) Various Combination of Protease Inhibitors, Oseltamivir, Favipiravir, and Chloroquin for COVID19: A Randomized Control Trial (THDMS-COVID19). https://clinicaltrials.gov/ct2/show/NCT04303299
Pereda, R., González, D., Rivero, H. B., Rivero, J. C., Pérez, A., Lopez, L. D. R., ... & Nodarse, H. (2020). Therapeutic effectiveness of interferon alpha 2b treatment for COVID-19 patient recovery. Journal of Interferon & Cytokine Research, 40(12), 578-588. https://doi.org/10.1101/2020.05.29.20109199
Pereda, R., González, D., Rivero, H. B., Rivero, J. C., Pérez, A., López, L. D. R., ... & Domínguez, R. E. (2020). Therapeutic effectiveness of interferon-?2b against COVID-19: the cuban experience. Journal of Interferon & Cytokine Research, 40(9), 438-442. https://instituciones.sld.cu/sci/files/2021/02/jir.2020.01241.pdf
Pinkovetskaia, I. (2019). Evaluación de la concentración del emprendimiento en las regiones de Rusia. Revista Científica Del Amazonas, 2(4), 18-26. Recuperado a partir de https://revistadelamazonas.info/index.php/amazonas/article/view/19
Prado-Mel E. (2020). Uso racional de medicamentos durante la pandemia por COVID-19. SANUM, 4(3), 4-5. https://revistacientificasanum.com/pdf/sanum_v4_n3_a0.pdf
RECOVERY Collaborative Group. (2020). Effect of hydroxychloroquine in hospitalized patients with Covid-19. New England Journal of Medicine, 383(21), 2030-2040. https://www.nejm.org/doi/full/10.1056/NEJMoa2022926
RECOVERY Collaborative Group. (2021). Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet. https://pubmed.ncbi.nlm.nih.gov/33933206/
Recovery Trial. (2020). RECOVERY COVID-19 phase 3 trial to evaluate Regeneron's REGN-COV2 investigational antibody cocktail in the UK. https://www.recoverytrial.net/news/recovery-covid-19-phase-3-trial-to-evaluate-regeneron2019s-regn-cov2-investigational-antibody-cocktail-in-the-uk
REMAP-CAP Investigators. (2021). Interleukin-6 receptor antagonists in critically ill patients with Covid-19. New England Journal of Medicine, 384(16), 1491-1502. https://www.nejm.org/doi/full/10.1056/NEJMoa2100433
Samudrala, P. K., Kumar, P., Choudhary, K., Thakur, N., Wadekar, G. S., Dayaramani, R., ... & Alexander, A. (2020). Virology, pathogenesis, diagnosis and in-line treatment of COVID-19. European Journal of Pharmacology, 883, 173375. https://pubmed.ncbi.nlm.nih.gov/32682788/
Sanders, J. M., Monogue, M. L., Jodlowski, T. Z., & Cutrell, J. B. (2020). Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a review. Jama, 323(18), 1824-1836. https://pubmed.ncbi.nlm.nih.gov/32282022/
Scagnolari, C., Vicenzi, E., Bellomi, F., Stillitano, M. G., Pinna, D., Poli, G., Clementi, M., Dianzani, F., & Antonelli, G. (2004). Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons. Antivir Ther, 9(6), 1003-11. https://pubmed.ncbi.nlm.nih.gov/15651759/
She, J., Jiang, J., Ye, L., Hu, L., Bai, C., & Song, Y. (2020). 2019 novel coronavirus of pneumonia in Wuhan, China: emerging attack and management strategies. Clinical and translational medicine, 9(1), 1-7. https://pubmed.ncbi.nlm.nih.gov/32078069/
Singhal, T. (2020). A review of coronavirus disease-2019 (COVID-19). The indian journal of pediatrics, 87(4), 281-286. https://pubmed.ncbi.nlm.nih.gov/32166607/
Sitio oficial de gobierno del Ministerio de Salud Pública en Cuba. (2021) Parte de cierre del día 10 de noviembre a las 12 de la noche. https://salud.msp.gob.cu.
Spinner, C. D., Gottlieb, R. L., Criner, G. J., López, J. R. A., Cattelan, A. M., Viladomiu, A. S…, & Marti, F. (2020). Effect of remdesivir vs standard care on clinical status at 11 days in patients with moderate COVID-19: a randomized clinical trial. Jama, 324(11), 1048-1057. https://www.ncbi.nlm.nih.gov/pubmed/32821939
Statista.com. U.S: National Center for Education Statistics (2021). Número acumulado de casos de coronavirus en el mundo desde el el 27 de enero de 2020 hasta el 9 de noviembre de 2021. https://es.statista.com/estadisticas/1104227/numero-acumulado-de-casos-de-coronavirus-covid-19-en-el-mundo-enero-marzo/
Statista.com. U.S: National Center for Education Statistics (2021). Número de casos confirmados de coronavirus en el mundo a fecha de 11 de noviembre de 2021, por país. https://www.statista.com/statistics/1043366/novel-coronavirus-2019ncov-cases-worldwide-by-country/
Tritany, R. F., & Tritany, É. F. (2020). Uso Racional de Medicamentos para COVID-19 na Atenção Primária à Saúde. Saúde em Redes, 6(2 Suplem). http://revista.redeunida.org.br/ojs/index.php/rede-unida/article/view/3205
Valdez-Cruz, N. A., García-Hernández, E., Espitia, C., Cobos-Marín, L., Altamirano, C., Bando-Campos, C. G., ... & Trujillo-Roldán, M. A. (2021). Integrative overview of antibodies against SARS-CoV-2 and their possible applications in COVID-19 prophylaxis and treatment. Microbial cell factories, 20(1), 1-32. https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-021-01576-5
Vanden Eynde, J. J. (2020). COVID-19: An update about the Discovery clinical trial. Pharmaceuticals, 13(5), 98. https://www.mdpi.com/1424-8247/13/4/65
Venero-Fernández, S. J., Gómez, M. M., Luna, L. C., de Armas Águila, Y., Medina, R. S., González, D. R. P., ... & Canga, J. R. V. (2021). Características epidemiológicas de la COVID-19 en La Habana, epicentro de Cuba. Revista Cubana de Higiene y Epidemiología, 58. http://www.revepidemiologia.sld.cu/index.php/hie/article/view/1025/1060
WHO Solidarity Trial Consortium. (2021). Repurposed antiviral drugs for COVID-19—interim WHO SOLIDARITY trial results. New England journal of medicine, 384(6), 497-511. https://pubmed.ncbi.nlm.nih.gov/33264556/
World Health Organization. (2020). Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected: interim guidance. In Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected: Interim guidance (pp. 21-21). https://apps.who.int/iris/handle/10665/330893
WHO. (2020). Corticosteroids for COVID-19: living guidance. https://apps.who.int/iris/handle/10665/334125
WHO. (2021). Therapeutics and COVID-19: living guideline. https://www.who.int/publications/i/item/WHO-2019-nCoV-therapeutics-2021.2
Zhao, M. (2020). Cytokine storm and immunomodulatory therapy in COVID-19: role of chloroquine and anti-IL-6 monoclonal antibodies. International journal of antimicrobial agents, 55(6), 105982. https://www.researchgate.net/publication/340712427_Cytokine_storm_and_immunomodulatory_therapy_in_COVID-19_Role_of_chloroquine_and_anti-IL-6_monoclonal_antibodies
Zillmer, J. G. V., & Díaz-Medina, B. A. (2018). Revisión Narrativa: elementos que la constituyen y sus potencialidades. Journal of Nursing and Health, 8
Cano, E. J., Fuentes, X. F., Campioli, C. C., O’Horo, J. C., Saleh, O. A., Odeyemi, Y., Yadav, H., & Temesgen, Z. (2021). Impact of corticosteroids in coronavirus disease 2019 outcomes: systematic review and meta-analysis. Chest, 159(3), 1019-1040. https://www.sciencedirect.com/science/article/pii/S0012369220351072
Cantini, F., Goletti, D., Petrone, L., Fard, S. N., Niccoli, L., & Foti, R. (2020). Immune therapy, or antiviral therapy, or both for COVID-19: a systematic review. Drugs, 1-18. https://europepmc.org/article/MED/33068263
Caponi, S., Brzozowski, F. S., Hellmann, F., & Bittencourt, S. C. (2021). O uso político da cloroquina: COVID-19, negacionismo e neoliberalismo/The political use of chloroquine: COVID-19, denialism and neoliberalism. Revista Brasileira de Sociologia-RBS, 9(21), 78-102. http://www.sbsociologia.com.br/rbsociologia/index.php/rbs/article/view/rbs.774
Casadevall, A., Dadachova, E., & Pirofski, L. A. (2004). Passive antibody therapy for infectious diseases. Nature Reviews Microbiology, 2(9), 695-703. https://pubmed.ncbi.nlm.nih.gov/15372080/
Casadevall, A., & Pirofski, L. A. (2020). The convalescent sera option for containing COVID-19. The Journal of clinical investigation, 130(4), 1545-1548. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108922/
Cavalcanti, A. B., Zampieri, F. G., Rosa, R. G., Azevedo, L. C., Veiga, V. C., Avezum, A. (2020). Hydroxychloroquine with or without azithromycin in mild-to-moderate Covid-19. New England Journal of Medicine, 383(21), 2041-2052. https://www.ncbi.nlm.nih.gov/pubmed/32706953
CECMED. Autorización de Uso de Emergencia (AUE) del producto Jusvinza. https://www.cecmed.cu/covid-19/aprobaciones/jusvinza-cigb-258-1
Choi, Y.J., Park, J.Y., Lee, H.S., Suh, J., Song, J.Y., Byun, M.K., Cho, J.H., Kim, H.J., Lee, J.H., Park, J.W., & Park, H.J. (2021). Effect of asthma and asthma medication on the prognosis of patients with COVID-19. European Respiratory Journal, 57(3). DOI: 10.1183/13993003.02226-2020
Chun Yam L.Y., Wing Lau A. C., Lin Lai F. Y., Shung E., Chan, J., & Wong, V. (2007). Corticosteroid treatment of severe acute respiratory syndrome in Hong Kong. Journal of Infection, 54(1), 28-39. https://www.sciencedirect.com/science/article/abs/pii/S0163445306000090
Ciapponi, A. (2020). El escándalo de la cloroquina. Evidencia, actualizacion en la práctica ambulatoria, 23(3), e002073-e002073. http://evidencia.org/index.php/Evidencia/article/view/6862
da Costa Braúna, C., Araujo, P. M., Carvalho, R. D., de Medeiros, M. D., & Nunes, L. C. (2021). Farmacoeconomia aplicada ao tratamento medicamentoso para a COVID-19 em um hospital campanha. Revista Eletrônica Acervo Saúde, 13(2). https://acervomais.com.br/index.php/saude/article/view/5971/4191
Descriptores en Ciencias de la Salud: DeCS. (2017). Sao Paulo (SP): BIREME / OPS / OMS. http://decs.bvsalud.org/E/homepagee.htm
Díaz, Y., Ramos-Suzarte, M., Martín, Y., Calderón, N. A., Santiago, W., Viñet, O., La O, Y., Oyarzábal, J., Pérez, Y., Lorenzo, G., Cepeda, M., Saavedra, D., Mazorra, Z., Estevez, D., Lorenzo-Luaces, P., Valenzuela, C., Caballero, A., Leon, K., Crombet, T., & Hidalgo, C.J. (2020). Use of a humanized anti-CD6 monoclonal antibody (itolizumab) in elderly patients with moderate COVID-19. Gerontology, 66(6), 553-561. https://pubmed.ncbi.nlm.nih.gov/33105142/
Dong, L., Hu, S., & Gao, J. (2020). Discovering drugs to treat coronavirus disease 2019 (COVID-19). Drug discoveries & therapeutics, 14(1), 58-60. https://pubmed.ncbi.nlm.nih.gov/32147628/
Food and Drug Administration. (2020). Fact sheet for healthcare providers: emergency use authorization (EUA) of bamlanivimab https://www.fda.gov/media/143603/download
Food and Drug Administration. (2020). Fact sheet for healthcare providers: emergency use authorization (EUA) of casirivimab and imdevimab. https://www.fda.gov/media/143892/download
Food and Drug Administration (2020). Remdesivir (VEKLURY). https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/214787Orig1s000lbl.pdf.
Gendrot, M., Javelle, E., Clerc, A., Savini, H., & Pradines, B. (2020). Chloroquine as a prophylactic agent against COVID-19? https://www.researchgate.net/publication/340597303_Chloroquine_as_prophylactic_agent_against_COVID-19
Gorbalenya A. E., Baker S. C., Baric, R.S., Groot, R.J., Drosten, C., Gulyaeva, A.A., Haagmans, B.L., Lauber, C., Leontovich, A.M., Neuman, B.W., Penzar, D., Perlman, S., Poon, L.L., Samborskiy, D.V., Sidorov, I.A., Sola, I., & Ziebuhr, J. (2020). The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nature microbiology, 5(4), 536. https://www.nature.com/articles/s41564-020-0695-z
Herrera, D., & Gaus, D. (2020). Enfermedad por covid-19 o sars-cov-2: guía clínica y de manejo. Práctica Familiar Rural, 5(1). https://practicafamiliarrural.org/index.php/pfr/article/view/146/188
Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., ... & Pöhlmann, S. (2020). SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. cell, 181(2), 271-280. https://www.sciencedirect.com/science/article/pii/S0092867420302294
Li, G., & De Clercq, E. (2020). Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nature reviews Drug discovery, 19(3), 149-150. https://pubmed.ncbi.nlm.nih.gov/32127666/
Liang, T. (2020). Handbook of COVID-19 prevention and treatment. The First Affiliated Hospital, Zhejiang University School of Medicine. Compiled According to Clinical Experience, 68. https://www.ephi.gov.et/images/novel_coronavirus/Handbook-of-COVID-19-Prevention-and-Treatment.pdf
Liu, J., Cao, R., Xu, M., Wang, X., Zhang, H., Hu, H., ... & Wang, M. (2020). Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. Cell discovery, 6(1), 1-4. https://www.ncbi.nlm.nih.gov/%20pubmed/32194981
Mehra, M. R., Desai, S. S., Ruschitzka, F., & Patel, A. N. (2020). RETRACTED: Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2820%2931180-6/fulltext
Mehta, P., McAuley, D. F., Brown, M., Sanchez, E., Tattersall, R. S., & Manson, J. J. (2020). COVID-19: consider cytokine storm syndromes and immunosuppression. The lancet, 395(10229), 1033-1034. https://pubmed.ncbi.nlm.nih.gov/32192578/
MeSH. (2002). U.S: National Library of Medicine. https://www.ncbi.nlm.nih.gov/mesh/
MINSAP. Protocolo de Actuación Nacional para la COVID-19 versión 1.1. (2021) https://covid19cubadata.github.io/protocolos/protocolo-version-1.pdf.
MINSAP. Protocolo de Actuación Nacional para la COVID-19 versión 1.2. (2021) https://covid19cubadata.github.io/protocolos/protocolo-version-2.pdf.
MINSAP. Protocolo de Actuación Nacional para la COVID-19 versión 1.3. (2021) https://covid19cubadata.github.io/protocolos/protocolo-version-3.pdf.
MINSAP. Protocolo de Actuación Nacional para la COVID-19 versión 1.4. (2021) https://covid19cubadata.github.io/protocolos/protocolo-version-4.pdf.
MINSAP. Protocolo de Actuación Nacional para la COVID-19 versión 1.5. (2021) https://covid19cubadata.github.io/protocolos/protocolo-version-5.pdf.
MINSAP. Protocolo de Actuación Nacional para la COVID-19 versión 1.6. (2021) https://covid19cubadata.github.io/protocolos/protocolo-version-6.pdf
NIH. COVID-19 Treatment Guidelines Panel. (2021) Coronavirus Disease 2019 (COVID-19) Treatment Guidelines. https://www.covid19treatmentguidelines.nih.gov/
NIH. U.S. National Library of Medicine. Clinical Trials. (2021) Various Combination of Protease Inhibitors, Oseltamivir, Favipiravir, and Chloroquin for COVID19: A Randomized Control Trial (THDMS-COVID19). https://clinicaltrials.gov/ct2/show/NCT04303299
Pereda, R., González, D., Rivero, H. B., Rivero, J. C., Pérez, A., Lopez, L. D. R., ... & Nodarse, H. (2020). Therapeutic effectiveness of interferon alpha 2b treatment for COVID-19 patient recovery. Journal of Interferon & Cytokine Research, 40(12), 578-588. https://doi.org/10.1101/2020.05.29.20109199
Pereda, R., González, D., Rivero, H. B., Rivero, J. C., Pérez, A., López, L. D. R., ... & Domínguez, R. E. (2020). Therapeutic effectiveness of interferon-?2b against COVID-19: the cuban experience. Journal of Interferon & Cytokine Research, 40(9), 438-442. https://instituciones.sld.cu/sci/files/2021/02/jir.2020.01241.pdf
Pinkovetskaia, I. (2019). Evaluación de la concentración del emprendimiento en las regiones de Rusia. Revista Científica Del Amazonas, 2(4), 18-26. Recuperado a partir de https://revistadelamazonas.info/index.php/amazonas/article/view/19
Prado-Mel E. (2020). Uso racional de medicamentos durante la pandemia por COVID-19. SANUM, 4(3), 4-5. https://revistacientificasanum.com/pdf/sanum_v4_n3_a0.pdf
RECOVERY Collaborative Group. (2020). Effect of hydroxychloroquine in hospitalized patients with Covid-19. New England Journal of Medicine, 383(21), 2030-2040. https://www.nejm.org/doi/full/10.1056/NEJMoa2022926
RECOVERY Collaborative Group. (2021). Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet. https://pubmed.ncbi.nlm.nih.gov/33933206/
Recovery Trial. (2020). RECOVERY COVID-19 phase 3 trial to evaluate Regeneron's REGN-COV2 investigational antibody cocktail in the UK. https://www.recoverytrial.net/news/recovery-covid-19-phase-3-trial-to-evaluate-regeneron2019s-regn-cov2-investigational-antibody-cocktail-in-the-uk
REMAP-CAP Investigators. (2021). Interleukin-6 receptor antagonists in critically ill patients with Covid-19. New England Journal of Medicine, 384(16), 1491-1502. https://www.nejm.org/doi/full/10.1056/NEJMoa2100433
Samudrala, P. K., Kumar, P., Choudhary, K., Thakur, N., Wadekar, G. S., Dayaramani, R., ... & Alexander, A. (2020). Virology, pathogenesis, diagnosis and in-line treatment of COVID-19. European Journal of Pharmacology, 883, 173375. https://pubmed.ncbi.nlm.nih.gov/32682788/
Sanders, J. M., Monogue, M. L., Jodlowski, T. Z., & Cutrell, J. B. (2020). Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a review. Jama, 323(18), 1824-1836. https://pubmed.ncbi.nlm.nih.gov/32282022/
Scagnolari, C., Vicenzi, E., Bellomi, F., Stillitano, M. G., Pinna, D., Poli, G., Clementi, M., Dianzani, F., & Antonelli, G. (2004). Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons. Antivir Ther, 9(6), 1003-11. https://pubmed.ncbi.nlm.nih.gov/15651759/
She, J., Jiang, J., Ye, L., Hu, L., Bai, C., & Song, Y. (2020). 2019 novel coronavirus of pneumonia in Wuhan, China: emerging attack and management strategies. Clinical and translational medicine, 9(1), 1-7. https://pubmed.ncbi.nlm.nih.gov/32078069/
Singhal, T. (2020). A review of coronavirus disease-2019 (COVID-19). The indian journal of pediatrics, 87(4), 281-286. https://pubmed.ncbi.nlm.nih.gov/32166607/
Sitio oficial de gobierno del Ministerio de Salud Pública en Cuba. (2021) Parte de cierre del día 10 de noviembre a las 12 de la noche. https://salud.msp.gob.cu.
Spinner, C. D., Gottlieb, R. L., Criner, G. J., López, J. R. A., Cattelan, A. M., Viladomiu, A. S…, & Marti, F. (2020). Effect of remdesivir vs standard care on clinical status at 11 days in patients with moderate COVID-19: a randomized clinical trial. Jama, 324(11), 1048-1057. https://www.ncbi.nlm.nih.gov/pubmed/32821939
Statista.com. U.S: National Center for Education Statistics (2021). Número acumulado de casos de coronavirus en el mundo desde el el 27 de enero de 2020 hasta el 9 de noviembre de 2021. https://es.statista.com/estadisticas/1104227/numero-acumulado-de-casos-de-coronavirus-covid-19-en-el-mundo-enero-marzo/
Statista.com. U.S: National Center for Education Statistics (2021). Número de casos confirmados de coronavirus en el mundo a fecha de 11 de noviembre de 2021, por país. https://www.statista.com/statistics/1043366/novel-coronavirus-2019ncov-cases-worldwide-by-country/
Tritany, R. F., & Tritany, É. F. (2020). Uso Racional de Medicamentos para COVID-19 na Atenção Primária à Saúde. Saúde em Redes, 6(2 Suplem). http://revista.redeunida.org.br/ojs/index.php/rede-unida/article/view/3205
Valdez-Cruz, N. A., García-Hernández, E., Espitia, C., Cobos-Marín, L., Altamirano, C., Bando-Campos, C. G., ... & Trujillo-Roldán, M. A. (2021). Integrative overview of antibodies against SARS-CoV-2 and their possible applications in COVID-19 prophylaxis and treatment. Microbial cell factories, 20(1), 1-32. https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-021-01576-5
Vanden Eynde, J. J. (2020). COVID-19: An update about the Discovery clinical trial. Pharmaceuticals, 13(5), 98. https://www.mdpi.com/1424-8247/13/4/65
Venero-Fernández, S. J., Gómez, M. M., Luna, L. C., de Armas Águila, Y., Medina, R. S., González, D. R. P., ... & Canga, J. R. V. (2021). Características epidemiológicas de la COVID-19 en La Habana, epicentro de Cuba. Revista Cubana de Higiene y Epidemiología, 58. http://www.revepidemiologia.sld.cu/index.php/hie/article/view/1025/1060
WHO Solidarity Trial Consortium. (2021). Repurposed antiviral drugs for COVID-19—interim WHO SOLIDARITY trial results. New England journal of medicine, 384(6), 497-511. https://pubmed.ncbi.nlm.nih.gov/33264556/
World Health Organization. (2020). Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected: interim guidance. In Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected: Interim guidance (pp. 21-21). https://apps.who.int/iris/handle/10665/330893
WHO. (2020). Corticosteroids for COVID-19: living guidance. https://apps.who.int/iris/handle/10665/334125
WHO. (2021). Therapeutics and COVID-19: living guideline. https://www.who.int/publications/i/item/WHO-2019-nCoV-therapeutics-2021.2
Zhao, M. (2020). Cytokine storm and immunomodulatory therapy in COVID-19: role of chloroquine and anti-IL-6 monoclonal antibodies. International journal of antimicrobial agents, 55(6), 105982. https://www.researchgate.net/publication/340712427_Cytokine_storm_and_immunomodulatory_therapy_in_COVID-19_Role_of_chloroquine_and_anti-IL-6_monoclonal_antibodies
Zillmer, J. G. V., & Díaz-Medina, B. A. (2018). Revisión Narrativa: elementos que la constituyen y sus potencialidades. Journal of Nursing and Health, 8
Publicado
2022-09-08
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Astorga González, B., & Dupotey Varela, N. M. (2022). Protocolos de tratamiento a la COVID-19: aproximación desde una perspectiva farmacoterapéutica. Orange Journal, 4(7), 16–32. https://doi.org/10.46502/issn.2710-995X/2022.7.02
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