Ethnopharmacological study of medicinal plants with activity on the Central nervous system in the Eastern Region of Cuba
DOI:
https://doi.org/10.46502/issn.2710-995X/2024.11.04Palabras clave:
Medicinal plants, Sedative, Hypnotic, and Anxiolytic Properties.Resumen
In the eastern region of Cuba, there is a traditional use of medicinal plants for various pharmacological purposes, although an inventory of these plant species necessary for the future search for new phytomedicines does not exist in all cases. This is the case for those used to treat central nervous system (CNS) disorders. To evaluate the traditional knowledge in two regions of Eastern Cuba: Santiago de Cuba and Holguín, regarding the use of medicinal plants with sedative, hypnotic, and anxiolytic effects, an ethnopharmacological study was conducted in two health areas of the main municipalities of these two provinces. A total of 400 people were surveyed, performing the socio-demographic characterization of the evaluated population as well as the qualitative characterization and evaluation of quantitative ethnopharmacological indicators such as the use value index and the significant use level of the medicinal plants used. The surveyed population in both provinces was predominantly female and over 60 years old, with a high level of preparation and professional training. A total of 27 plants were reported in the interviews conducted among the 1637 citations obtained, with similar results between the two provinces. The highest number of citations in both regions corresponded to plants used as sedatives, followed by hypnotics, and finally anxiolytics. Among the most used parts of these plants, the use of leaves prepared in the form of infusions predominated. Of the 8 plant species with the highest acceptance by the population, the plants P. neochilus, J. pectoralis, L. inermis, and P. incarnata obtained the best values for the evaluated ethnopharmacological indicators.
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American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (DSM-5). American Psychiatric Association.
Begum, Z., & Younus, I. (2018). Hibiscus rosa sinensis mediate anxiolytic effect via modulation of ionotropic GABA-A receptors: possible mechanism of action. Metabolic brain disease, 33, 823-827. https://doi.org/10.1007/s11011-018-0188-4
Chaachouay, N., Benkhnigue, O., & Zidane, L. (2020). Ethnobotanical study aimed at investigating the use of medicinal plants to treat nervous system diseases in the Rif of Morocco. Journal of chiropractic medicine, 19(1), 70-81. https://doi.org/10.1016/j.jcm.2020.02.004
Ferreiro, A. O. R. (2023). Neuropharmacological activity of leaf extract of Plectranthus neochilus Schltr. grown in Cuba (Doctoral dissertation), University of Antwerp.
Gao, L, Wei, N, Yang, G, Zhang, Z, Liu, G, & Cai, C. (2019). Ethnomedicine study on traditional medicinal plants in the Wuliang Mountains of Jingdong, Yunnan, China. J. ethnobiol. ethnomed, 15(41), 1-20. https://doi.org/10.1186/s13002-019-0316-1
Gebre, T., & Chinthapalli, B. (2021). Ethnobotanical study of the traditional use and maintenance of medicinal plants by the people of Aleta-Chuko woreda, south Ethiopia. Pharmacognosy Journal, 13(5). http://dx.doi.org/10.5530/pj.2021.13.142
Germosén-Robineau, L. (1995). Hacia una farmacopea vegetal caribeña. Edición TRAMIL 7. Santo Domingo: Enda Caribe, UAG & Universidad de Antioquia.
Guimarães, T. L. F., Silva, L. M. R. D., Lima, C. D. B., Magalhães, F. E. A., & Figueiredo, E. A. T. D. (2020). Antimicrobial activity of microcapsules with aqueous extract of chambá (Justicia pectoralis Jacq). Revista Ciência Agronômica, 51(2), e20186471. https://doi.org/10.5935/1806-6690.20200033
Gupta, A., & Yadav, J. S. (2023). A Review On Miraculous Herb For The Treatment Of Depression: Passiflora Incarnata. Journal of Survey in Fisheries Sciences, 3886-3892. https://doi.org/10.53555/sfs.v10i1.1782
Heredia-Díaz, Y., García-Díaz, J., López-González, T., Chil-Nuñez, I., Arias-Ramos, D., Escalona-Arranz, J. C., ... & Martínez-Figueredo, Y. (2018). An ethnobotanical survey of medicinal plants used by inhabitants of Holguín, Eastern Region, Cuba. Bol Latinoam Caribe Plant Med Aromat, 17(2), 160-196.
Hossain, M. L., & Sultana, S. (2019). In-vivo assessment of neuropharmacological activity of methanol bark extract of Mimosa pudica in mice. Adv. Pharmacol. Pharm, 7(2), 33-37. https://doi.org/10.13189/app.2019.070202
Hurtado R., & Moraes, M. (2010). Comparación del uso de plantas por dos comunidades campesinas del bosque tucumano-boliviano de Vallegrande (Santa Cruz, Bolivia). Ecología en Bolivia, 45(1), 20-54.
Khalid, L., Rizwani, G. H., Sultana, V., Zahid, H., Khursheed, R., & Shareef, H. (2014). Antidepressant activity of ethanolic extract of Hibiscus rosa sinenesis Linn. Pakistan Journal of Pharmaceutical Sciences, 27(5).
Kryger, M. H., Roth, T., & Dement, W. C. (2010). Principles and Practice of Sleep Medicine-E-Book: Expert Consult-Online and Print. Elsevier Health Sciences.
Leyva, C. S., Tagle, L. J., Teofilo, C. A., Hernández, J. G., Cordero, S. C., Franco, G. F., & Sánchez, D. O. S. (2022). Estudio etnofarmacológico y fitoquímico de las plantas medicinales de mayor uso en Julián Blanco, Guerrero, México. Acta Agrícola y Pecuaria, 8(1), 1-13. https://doi.org/10.30973/aap/2022.8.0081012
Lima, A. R. S., Lôbo, L. A. C., Costa, T. L. D. C., Peixoto, J. D. C., Borges, L. L., Amaral, V. C. D. S., & Paula, J. A. M. D. (2020). Eco-friendly extraction and simultaneous determination of two coumarins in Justicia pectoralis (Acanthaceae). Rodriguésia, 71, e01132019. https://doi.org/10.1590/2175-7860202071041
López Sáez, J. A., & Pérez Soto, J. (2010). Permanencia y transmisión del acervo botánico etnomedicinal en la Isla de Ometepe (Nicaragua). Revista Española de Antropología Americana, 40(2), 125-144
Luthra, R., & Roy, A. (2022). Role of medicinal plants against neurodegenerative diseases. Current pharmaceutical biotechnology, 23(1), 123-139. https://doi.org/10.2174/1389201022666210211123539
Malla, B., Gauchan, D. P., & Chhetri, R. B. (2015). An ethnobotanical study of medicinal plants used by ethnic people in Parbat district of western Nepal. Journal of ethnopharmacology, 165, 103-117. https://doi.org/10.1016/j.jep.2014.12.057
Ministerio de Salud Pública [MINSAP]. (2017). Formulario Nacional de Fitofármacos y Apifármacos. Segunda Edición. La Habana, Cuba: Editorial Ciencias Médicas.
Mostacero-León, J., García-Izquierdo, L. G., López-Medina, S. E., Anthony, J., & Gil-Rivero, A. E. (2022). Valor de uso medicinal de la flora empleada por la Comunidad Andina de Jesús, Cajamarca, Perú. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 21(5), 561-576. https://doi.org/10.37360/blacpma.22.21.5.34
Moutawalli, A., Benkhouili, F. Z., Doukkali, A., Benzeid, H., & Zahidi, A. (2023). The biological and pharmacologic actions of Lawsonia inermis L. Phytomedicine Plus, 3(3), 100468. https://doi.org/10.1016/j.phyplu.2023.100468
Naldi, J., Ginting, I., Rudang, S. N., & Ramadayanti, S. (2022). Sedative Test of Ethanol Extract of Putri Malu Leaves (Mimosa Pudica Linn.) in Mice (Mus Musculus) With Standardized Herbal Medicine Lelap as Comparison. Journal La Medihealtico, 3(2), 110-115. https://doi.org/10.37899/journallamedihealtico.v3i2.579
Nikolova, K., Velikova, M., Gentscheva, G., Gerasimova, A., Slavov, P., Harbaliev, N., ... & Gavrilova, A. (2024). Chemical Compositions, Pharmacological Properties and Medicinal Effects of Genus Passiflora L.: A Review. Plants, 13(2), 228. https://doi.org/10.3390/plants13020228
Oficina Nacional de Estadística e Información (ONEI). (2023). El envejecimiento de la población. Cuba y sus territorios 2022. República de Cuba. http://www.onei.gov.cu/sites/default/files/envejecimiento_2022_.pdf
Puig, P. L., Millian, A. J. G., Carbonell, L. A., Perdomo, J., & Pérez, A. S. (2019). Integration of Cuban natural and traditional medicine in the health system. Revista Cubana de Salud Pública, 45(2), 1-24.
Rahman, M. H., Bajgai, J., Fadriquela, A., Sharma, S., Trinh, T. T., Akter, R., ... & Lee, K. J. (2021). Therapeutic potential of natural products in treating neurodegenerative disorders and their future prospects and challenges. Molecules, 26(17), 5327. https://doi.org/10.3390/molecules26175327
Rang, H. P., Dale, M. M., Ritter, J. M., & Moore, P. K. (2016). Pharmacology. Elsevier.
Rao, R. R. (2019). Medicinal plants of India: diversity, conservation and bioprospection-concerns and strategies for 21st century. Medicinal plants of India: Conservation and sustainable use, 1, 1-38.
Salmerón-Manzano, E., Garrido-Cardenas, J. A., & Manzano-Agugliaro, F. (2020). Worldwide research trends on medicinal plants. International journal of environmental research and public health, 17(10), 3376. https://doi.org/10.3390/ijerph17103376
Sharifi-Rad, M., Lankatillake, C., Dias, D. A., Docea, A. O., Mahomoodally, M. F., Lobine, D., ... & Sharifi-Rad, J. (2020). Impact of natural compounds on neurodegenerative disorders: from preclinical to pharmacotherapeutics. Journal of Clinical Medicine, 9(4), 1061. https://doi.org/10.3390/jcm9041061
Sultana, S., & Hossain, M. L. (2019). Evaluation of Anxiolytic and Antibacterial Activity of Methanol Extract of Leaves of Mimosa pudica. Universal Journal of Plant Science, 7(3), 44-49. https://doi.org/10.13189/ujps.2019.070302
Teixeira Pires Gomides, N. A. M., Guarim Neto, G., Pereira Martins, M., Kato, L., & Pasqualotto Severino, V. G. (2022). Ethnobotanical and ethnopharmacological survey of medicinal species utilized in the Coqueiros Community, Brazil. Boletin Latinoamericano y Del Caribe de Plantas Medicinales y Aromaticas, 21(6). https://doi.org/10.37360/blacpma.22.21.6.42
Upadhyay, H.C. (2023). Exploring Nature’s Treasure for Drug Discovery. Letters in Drug Design & Discovery, 20(4), 373-374. https://doi.org/10.2174/157018082004230113144404
Urdaneta, Y. F., González, T. L., & Pacheco, A. O. (2022). Folklore medicinal del culantro (Eryngium foetidum L.). Orange Journal, 4(7), 45-55. https://doi.org/10.46502/issn.2710-995X/2022.7.04
Urdaneta-Laffita, I., Padró-Rodríguez, L., Tur-Naranjo, E., & Nápoles-Garzón, I. (2021). Etnofarmacología de plantas medicinales con efectos sedantes en la comunidad Songo, Santiago de Cuba. Orange Journal, 3(6), 4-13. https://doi.org/10.46502/issn.2710-995X/2021.6.01
Wahid, M., Ali, A., Saqib, F., Aleem, A., Bibi, S., Afzal, K., ... & Bin Asad, M. H. H. (2020). Pharmacological exploration of traditional plants for the treatment of neurodegenerative disorders. Phytotherapy research, 34(12), 3089-3112. https://doi.org/10.1002/ptr.6742
Zanardi, R., Carminati, M., Fazio, V., Maccario, M., Verri, G., & Colombo, C. (2023). Add-On Treatment with Passiflora incarnata L., herba, during Benzodiazepine Tapering in Patients with Depression and Anxiety: A Real-World Study. Pharmaceuticals, 16(3), 426. https://doi.org/10.3390/ph16030426
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